Numerous diseases, such as Alzheimer’s, Parkinson’s, and HIV, can cause dementia. Dementia is not a single disease, but many syndromes, resulting in complex patterns of brain changes and losses in cognition. Cognitive losses contribute to the development of mood disorders and the onset of disruptive behaviors. Challenging behaviors known as dementia-related behavioral symptoms (DRBS) are observed in as 80-95% of persons with dementia. This course will review activators of DRBS.